While construction cranes may come and go, Mayo Clinic’s long-term vision for its Jacksonville campus is here to stay. As a cornerstone of the city’s healthcare community, the nonprofit isn’t just adding cutting-edge buildings—it’s shaping the future of medicine in the region, with plans that could eventually double its presence in Northeast Florida.
The signs of growth are impossible to miss at its campus on San Pablo Road. A new hotel is nearly finished, a major hospital expansion is underway, and this July, Mayo will open a state-of-the-art cancer center featuring North America’s first carbon ion therapy unit.
But these visible projects are only part of a much broader plan.
Mayo is working from a long-range strategy that spans nearly 90 years into the future. This master plan, backed by more than $1 billion in investment, supports the clinic’s mission to be a destination for complex, high-level care.
“We’ve got the land and flexibility to think big—transportation, infrastructure, you name it,” said Dr. Kent Thielen, CEO of Mayo Clinic in Florida. “Of course, no one can predict exactly what healthcare will look like in 10 or 15 years, but we’re building with that in mind.”
Planning decades ahead
This long-term approach is part of what sets Mayo apart. While some of the progress might seem slow, it’s intentional—designed to balance global medical ambitions with local infrastructure planning.
The campus itself spans 602 acres, with the main 392-acre site and a newer 210-acre North Campus acquired in 2022. While the North Campus remains largely undeveloped, it’s expected to play a key role in future expansion.
Earlier this year, the City of Jacksonville approved a $4.6 million permit to prepare 40 acres of that North Campus, but don’t expect construction to start just yet.
“There are no buildings planned for this year,” said Thielen. “We’re focused on preparing the land with roads and utilities, laying the groundwork for whatever comes next.”
Few institutions take on planning this far into the future, but Mayo sees it as essential for staying ahead in clinical care, research, and education.
Visible growth on the main campus
While the North Campus is still in its early stages, Mayo’s main campus is actively growing.
A new 252-room Hilton hotel with a conference center is set to open in October. It’s designed to better serve patients, families, visiting doctors, and trainees—especially since about half of Mayo’s patients come from outside Jacksonville, with some traveling from across the globe.
In fact, patients from over 80 countries have been treated at the Jacksonville location, and that number continues to grow by about 20% each year.
“Our focus remains on complex care for patients with serious conditions,” Thielen explained. “We see ourselves as a complement to the broader healthcare ecosystem here in Jacksonville.”
Elsewhere on the campus, a five-story hospital expansion—costing around $130 million—is opening in phases, with final completion expected by the end of 2026.
July will also mark the opening of Mayo’s new Integrated Oncology Building. This flagship project will introduce carbon ion therapy to North America for the first time.
A first for the continent
Carbon ion therapy is a highly advanced cancer treatment used at only a handful of centers worldwide. It targets tumors more precisely than conventional therapies, minimizing damage to healthy tissue. Mayo already leads the U.S. in delivering proton therapy and sees this as the next evolution.
The aim is to eventually make this treatment available to up to 60,000 American cancer patients each year who have few or no remaining treatment options. It’s a major step forward in cancer care and research.
Even though the number of cranes on Mayo’s campus has dropped from a peak earlier this year, construction remains steady. But for Thielen, the real engine behind Mayo’s success isn’t the buildings—it’s the people.
“We talk a lot about technology and beautiful facilities,” he said, “but the real strength of Mayo Clinic is our people.”
A billion-dollar-plus investment
Since 2000, Mayo Clinic has been linked to over 1,600 building permits in Duval County, representing roughly $1.3 billion in local investment, according to Business Journal analysis. And that doesn’t even count future projects in the planning stage.
With global ambitions and a 90-year timeline, Mayo Clinic is laying the groundwork to make Jacksonville a national leader in healthcare for decades to come.
Information from: https://www.bizjournals.com/jacksonville/news/2025/05/23/mayo-clinic-jacksonville-expansion-look-forward.html
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